screw up：拧紧；强迫；加强；弄糟；搞砸。

【例句】
She had screwed up her eyes, as if she found the sunshine too bright.
她眯起了眼睛，好像是觉得阳光太刺眼。

I think I screw up the test yesterday.
我想昨天的考试，我搞砸了。