be down and out 穷困潦倒；穷困

【例句】
The English-speaking countries are widely perceived to be down and out after housing binges and financial busts.
经历过住房热潮和金融崩溃之后，人们普遍认为英语国家将陷于穷困潦倒。

When you be down and out, something always turn up.
当你处于山穷水尽之际，常会有些东西在你面前翻起来。