first and last

Altogether; on the whole; primarily; above all
(考虑到一切因素)总的说来，整体看来;主要地;完全

First and last, be sure to be true to your own desires.
说到底，你都要忠于你自己的意愿。

The book is, first and last, an account of a poet's development.
这本书，说到底，就是对一位诗人发展的记述。

千万不要和from first to last记混， from first to last的意思是"从始至终(from start to finish)" 或者是 "贯穿(throughout)"

We cheered them on from first to last.
我们自始至终为他们加油。