in the least 至少;丝毫;绝

【例句】
I'm not in the least suggesting that it will cure world wide obesity, but it's something that could make a difference.
我丝毫没有表明这是治疗肥胖的灵丹妙药，但它确实能够产生作用。

That is acceptable to me in the least.
对我来说没有丝毫值得接受。