pain in the ass字面意思屁股痛，然而它的延伸意思却是眼中钉，肉中刺，指令人讨厌的人。

【例句】
He also said you were the biggest pain in the ass he'd ever met.
他还说你是他见过的最厉害的眼中钉。

He may be a superstar, but most parents consider him a pain in the ass.
他可以算是超级明星，但大多数家长觉得他很讨厌。