nose to the grindstone翻译为“埋头苦干”,形容一个人全神贯注地工作，努力不懈。

【例句】
You have to study for your exam, so put your nose to the grindstone!
你必须为了考试好好复习，所以需要埋头读书！

I have a big project due tomorrow, so I need to put my nose to the grindstone and work on it all night.
我明天有一个大项目要交，所以我需要整晚埋头苦干。