with your eyes open不是你的眼睛要睁开，而是明明知道有问题；明知后果如何；心里有数。

【例句】
I went into this with my eyes open so I guess I only have myself to blame.
我是明明知道做这事的后果的，所以我想只能责怪我自己。

She lent the credit card to her cousin with her eyes open.
明知道有问题，她还是把信用卡借给表弟了。