表达 “hit the road” 通常被用在某人正要或即将踏上一段旅程时，意思是 “出发，上路”。它也常用来提出自己就要 “离开一个活动，比如一场聚会”。

例句
We’re going to hit the road early tomorrow to start our trip across the US. Make sure you have a good night’s sleep!
咱们明天一大早就要上路，踏上横穿美国的旅行。你一定要睡个好觉！

Look at the time! I really enjoyed the party, but I think it’s time we hit the road!
都这个点了！这次聚会我玩得很开心，但我想我们该走了！

She likes to avoid rush hour on her daily commute to work by hitting the road early morning.
她喜欢一大早就出门，避开每天的上班高峰期。