表达 “be at your wits' end” 的意思是 “因找不到解决问题的办法而感到一筹莫展、束手无策，不知道下一步该怎么办”。

例句
My baby won't stop crying. I'm at my wits' end about what to do next.
我的宝宝一直哭个不停。我完全不知道该怎么办。

I'm at my wits' end trying to understand this work schedule – I don't know what I should be doing now.
我绞尽脑汁想弄明白这个工作日程安排表，但还是没看懂。我真不知道现在该做什么。

He's at his wits' end trying to find enough money to pay his rent. He could be evicted any day.
他绞尽脑汁想凑钱付房租，却一筹莫展。他随时都有可能被赶出去。