screw sb up 使（某人）焦虑不安，令（某人）很难过；使（某人）精神崩溃。
如screw v. 将（尤指纸或布）揉成团。出现screw sth up也要结合句意。
to twist and crush something, especially paper or cloth, roughly with your hands
 
【例句】
I totally screwed up the chemistry exam.
化学考试被我彻底考砸了。
 
It really screwed him up when he saw his friend get killed.
看到自己的朋友遇难，他伤心欲绝。
 
She screwed the bag up and threw it in the bin.
她把包揉成一团，扔进了垃圾筒。