A: How's your business?
B: Everything seems to be getting worse. I don't know what to do with it.
A: Things are tough all over. You should never give up!
B: OK, OK. I'll do my best.

A: 生意做得怎样？
B: 一切似乎每下愈况。我不知道该怎么办。
A: 万事皆难。你绝对不能放弃！
B: 好吧。我会全力以赴。

重点解说：

★ get worse「恶化」cf. go from bad to worse「每下愈况」get better「有起色」

★ I don't know what to do with it.也可说成I'm at a loss what to do.

★ Things are tough all over.「 万事皆难。」此语用于表示凡事均须付出代价，世上没有什么事是轻松容易的。近似的说法还有"No pains, no gains." "Nothing venture, nothing have [gain]."「没有不劳而获的事。」

★ give up「放弃」

★ do one's best「全力以赴」